melatonin is a horomone and doesnt get you high just regulates how you should sleep

coffee or caffeine inhibits your bodies ability to relax ur muscles (by mimicking adenosine i think) but doesnt make you high or more awake (like people seem to think). could cause a heart attack tho but that’s super rare if ur a normal person.

i take it you havent dabbled much in the drug world, so id remain ignorant. its more blissful. but if you really want to dabble please research yourself and not news articles. actual studies. news articles will lie and propagate misinfo.