Every manager I’ve encountered requires unlocking before it’ll fill anything in, meaning it is MFA usually

The 3 factor types are something you are, know, and have. On my phone for example I unlock my device with a pin code and my password manager with biometrics (know & are)

It gets iffier on desktop devices for sure but if you get a cheapo fingerprint scanner you can make it guaranteed MFA ezpz, unlock the PC with your fingerprint and enter your password to get to the password manager