I wonder if Bud Tucker in Double Trouble would still run. Probably would need dosbox

Anyway, whole adventure genre. Syberias, Mysts, Gabriel Knight

I’ve found Shadowrun trilogy fun

Darkest Dungeon, Oxygen not Included, Surviving Mars
Citizen Sleeper is short but well done, got me hooked to finish it in a single sitting
Arcanum I still consider one of the best RPGs ever made
Fallout 1&2

I don’t know if Commandos style games would not require too fast clicking without a keyboard, but you could try out Shadow Tactics, it has active pause IIRC
Speaking of Commandos, Jagged Alliance was fun too